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The animals were divided into four groups, as follows: group 1 control: no treatment; group 2: rapamycin (2 mg/kg); group 3 FK506 (0, 3 mg/kg); and group 4: FK506 (0, 3 mg/kg) plus rapamycin (2 mg/kg). The left kidney was removed and after 3 h of cold ischaemia, the graft was transplanted. Twenty-four hours after transplant, the kidney was recovered for histological analysis and cytokine expression. Preconditioning treatment with rapamycin or tacrolimus significantly reduced blood urea nitrogen and creatinine compared with control [blood urea nitrogen (BUN): P < 0·001 versus control and creatinine: P < 0·001 versus control]. A further decrease was observed when rapamycin was combined with tacrolimus. Acute tubular necrosis was decreased significantly in donors treated with immunosuppressants compared with the control group (P < 0·001 versus control). Moreover, the number of apoptotic nuclei in the control group was higher compared with the treated groups (P < 0·001 versus control). 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Next 6 Hours Prev 6 Hours You wouldn't expect to find a really good Neapolitan pizza place right on the main drag in a little town like Salem, but here we are, and here you should be too. They have the wood-fired oven that chars the crust of your pizza in two minutes, and though some of their ingredient combinations didn't appeal, we were easily able to find two that we liked. The pizzas are 11 inches, but very thin, as is the style, so if you're hungry you can probably finish one by yourself. You do pay a bit more for this pizza than you would elsewhere, but it's worth it. I was surprised to be one of the few patrons on a Sunday afternoon, so I really hope they do better business at dinnertime, because this place was a real find. lingerie baby doll bra string corset Stock 20 venduti BASIC COLLECTION - Design&Innovation STATH Turks And Caicos Islands lingerie per uomo | Scopri ulteriori informazioni lingerie per uomo | Per ulteriori informazioni lingerie per uomo | Per più
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