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We studied the effect of different dietary lipids on the outcome of a permanent ischemic stroke rat model. Methods: Wistar rats were fed diets containing 7% commercial oils (S, soybean; O, olive; C, coconut; G, grape seed) for 35 d. Stroke was induced by permanent middle cerebral artery occlusion. Coronal slices from ischemic brains and sham-operated animals were supravitally stained. Penumbra and core volumes were calculated by image digitalization after 24, 48, and 72 h poststroke. Homogenates and mitochondrial fractions were prepared from different zones and analyzed by redox status, inflammatory markers, ceramide, and arachidonate content, phospholipase A2, NOS, and proteases. Results: Soybean (S) and G diets were mainly prooxidative and proinflammatory by increasing the liberation of arachidonate and its transformation into prostaglandins. O was protective in terms of redox homeostatic balance, minor increases in lipid and protein damage, conservation of reduced glutathione, protective activation of NOS in penumbra, and net ratio of anti-to proinflammatory cytokines. Apoptosis (caspase-3, milli- and microcalpains) was less activated by O than by any other diet. Conclusion: Dietary lipids modulate NOS and PLA2 activities, ceramide production, and glutathione import into the mitochondrial matrix, finally determining the activation of the two main protease systems involved in programmed cell death. Olive oil appears to be a biological source for the isolation of protective agents that block the expansion of brain core at the expense of penumbral neurons. Navigation  Aggiungi al carrello Equipment OpenTable for iOS © 2010-2018, Amazon.com, Inc. o società affiliate. Luckily, I decided that I need to end the strip a year before it actually ended, so I had a lot of time to plan. Personally, I’d been going through what depressed people like to call “some head stuff,” and it was affecting both the tone of the strip and my productivity. Even with therapy, I didn’t see it ending anytime soon, and I didn’t want to drag the characters through my muck. I knew I needed a change in my routine anyway. Ten years of constantly thinking about the next strip and checking to make sure the website was up, even on my days off, had become utterly exhausting. I decided to end the strip while it was still something I loved, rather than let it keep going until I gave up on it. The characters, and my readers, deserved better than a fizzled-out ending. So I planned. 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