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The aim of this paper is to establish a relationship between the ischemic reperfusion injury with the long-term survival Ten intestinal transplants were analyzed in adult, Wistar, inbred, male rats. Light microscopical examination was performed on intestine graft: 1) immediately post-dissection, 2) at the end of cold isquemia, 3) 30 min, 4) 48hs and 5) 5 days post-transplant procedure, respectively. Biopsies were reported according to Park's classification and extension of staining using immunohistochemestry to malondialdehyde (MDA) products. The Park's classification indexes reported in samples were 1) 0,57 +/- 1,13 (N=10); 2) 2,71 +/- 1,25 (N=10); 3) 4,14 +/- 0,89 (N=10); 4) 1,0 +/- 0,81 (N=7); 5) 0 (N=7). The highest levels of immunohistochemical detection of MDA were observed thirty minutes post-reperfusion (extension of staining between 51% to 75%). Three animals died when they were sampled at 48 hours, and the biopsies had Park's classification > or = 4 at 30 minutes post-reperfusion and endotoxemic signology. The highest degree of mucosal damage was observed immediately post-reperfusion. At 48hs the graft tended to be normalized Failure to repair the immediately I-R injury signficantly affects the long term survival. Bambina 2 - 14 anni Maglie e Felpe Tutto il mondo Taiwan Montenegro I’m also planning on taking a month-long trip fully unplugged, without a phone or a laptop. I won’t be allowed to look at screens or receive text messages, relying on printed media and human interaction for my news and information. 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STRINGC Brazil Cancella tutti i filtri Mostra riepilogo - Setting The Pace Solid organ transplantation is inherently associated to ischemia reperfusion injury (IRI) since the operative procedure always implies the harvesting, preservation and implantation of the organ, which result in several hours of ischemia followed by reperfusion. Several strategies have been proposed to mitigate IRI in organ transplantation. However, most of them are in experimental phases and currently few are implemented in the clinical field. These strategies can be applied in 3 different stages of the transplantation procedure: on the organ donor, known as donor pretreatment; during preservation, when ischemic organ is waiting to be implanted in the recipient or on the transplant recipient. In the present review, we will discuss the different approaches to control IRI damage in solid organ transplantation and the rationale behind them. 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