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Kidneys from brain dead donors show lower success rates than kidneys from living donors and one strategy to improve transplantation outcome is to precondition the donors. For the first time, anti-rat thymoglobulin (rATG) was administered in an experimental brain death animal model to evaluate if it could ameliorate histopathological damage and improve organ function. Animals were divided into three groups: V (n=5) ventilated for 2h; BD (n=5) brain death and ventilated for 2h; and BD+rATG (n=5) brain death, ventilated for 2h, rATG was administered during brain death (10mg/kg). We observed lower creatinine levels in treatment groups (means): V, 0·88±0·22 mg/dl; BD, 1·37±0·07 mg/dl; and BD+rATG, 0·64±0·02 mg/dl (BD versus BD+rATG, P<0·001). In the BD group there appeared to be a marked increase of ATN, whereas ATN was decreased significantly in the rATG group (V, 2·25±0·5 versus BD, 4·75±0·5, P<0·01; BD+rATG, 2·75±0·5 versus BD 4·75±0·5 P<0·01). Gene expression was evaluated with reverse transcription-polymerase chain reaction; tumour necrosis factor (TNF)-α, interleukin (IL)-6, C3, CD86 showed no significant difference between groups. Increased IL-10 and decreased CCL2 in BD+rATG compared to BD (both cases P<0·01). Myeloperoxidase was increased significantly after the brain death setting (V: 32±7·5 versus BD: 129±18). Findings suggest that rATG administered to potential donors may ameliorate renal damage caused by BD. These findings could contribute in the search for specific cytoprotective interventions to improve the quality and viability of transplanted organs. turchese(2) soft 0 ✿ Ci auguriamo che tu abbia una soddisfacente esperienza di acquisto nel nostro negozio. 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Uniform Shop Atlanta / GeorgiaBaltimore AreaBoston / New EnglandChicago / IllinoisDallasDenver / ColoradoHoustonLas VegasLos AngelesMiami / Southeast FloridaMinneapolisNew Orleans / LouisianaNew York AreaOrange CountyPhiladelphia AreaPhoenixSan DiegoSan Francisco Bay AreaSeattle AreaTucsonWashington DC Your order may be subject to duties and taxes. If this is the case, eShopWorld will contact you to make payment arrangements prior to your package being delivered. All payments for duties and taxes will be made directly to eShopWorld on their web site. Radar.js v20.95. Copyright 2018 Cedexis. All rights reserved. Venezia 75 Il reggiseno ideale per seno cadente o seno svuotato è, in linea generale, un push-up dalla coppa scollata e piccola; oppure, un classico reggiseno con ferretto che abbia le coppe separate e che riesca a contenere al meglio entrambi i seni. 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