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IRI is an independent antigen inflammatory process that produces tissue damage. Our objective was to study the impact of immunosuppressive treatment (IS) on IRI applying only one dose of IS before orthotopic kidney autotransplantation. Twenty-four rats allocated in four groups were studied. One group served as control (G1: autotransplanted rats without IS) and the rest received IS 12 h before kidney autotransplantation (G2: Rapamycin, G3: Mycophenolate mofetil and G4: Tacrolimus). Improved renal function and systemic inflammatory response were found among IS groups compared to the control group (Delta Urea p<0.0001; Delta Creatinine p<0.0001; Delta C3 p<0.001). The number of apoptotic nuclei in renal medulla in G1 was higher than in IS groups (p<0.0001). Tubular damage was less severe in IS groups respecting G1 (p<0.001). C3, TNF-α and IL-6 expression in kidney samples was reduced when IS was used compared to the control group. No differences were observed among the different immunosuppressive drugs tested. However, Heme oxygenase-1(HO-1) was increased only in Rapamycin treatment. These data suggest that the use of IS administered before transplant attenuates the IRI process after kidney transplantation in an animal model. Eater Young Guns Nominations, Cleve’s Favorite Drinks, and More Updates to Start the Week SLOGGI SWIM WOW COMFORT MELLOW Slip bikini hipster STROKET Central America Group Tour Il Formal maschile Courtesy of©andresr/iStock 17 euro un paio di calzini???? dai cinesi me ne compro 17 paia!!!! Gli anni 1940[modifica | modifica wikitesto] a rete | Ulteriori informazioni di a rete | Ulteriori informazioni su o su a rete | Ulteriori informazioni sul nostro sito Web
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